By:Abdelaziz, HM (Abdelaziz, Hadeer M.)^[ 1,2 ] ; Gaber, M (Gaber, Mohamed)^[ 1 ] ; Abd-Elwakil, MM (Abd-Elwakil, Mahmoud M.)^[ 1 ] ; Mabrouk, MT (Mabrouk, Moustafa T.)^[ 1,2 ] ; Elgohary, MM (Elgohary, Mayada M.)^[ 1,2 ] ; Kamel, NM (Kamel, Nayra M.)^[ 1,2 ] ; Kabary, DM(Kabary, Dalia M.)^[ 1,2,3 ] ; Freag, MS (Freag, May S.)^[ 1,4 ] ; Samaha, MW (Samaha, Magda W.)^[ 1,2 ] ; Mortada, SM (Mortada, Sana M.)^[ 1,2 ]...More

There is progressive evolution in the use of inhalable drug delivery systems (DDSs) for lung cancer therapy. The inhalation route offers many advantages, being non-invasive method of drug administration as well as localized delivery of anti-cancer drugs to tumor tissue. This article reviews various inhalable colloidal systems studied for tumor-targeted drug delivery including polymeric, lipid, hybrid and inorganic nanocarriers. The active targeting approaches for enhanced delivery of nanocarriers to lung cancer cells were illustrated. This article also reviews the recent advances of inhalable microparticle-based drug delivery systems for lung cancer therapy including bioresponsive, large porous, solid lipid and drug-complex microparticles. The possible strategies to improve the aerosolization behavior and maintain the critical physicochemical parameters for efficient delivery of drugs deep into lungs were also discussed. Therefore, a strong emphasis is placed on the approaches which combine the merits of both nanocarriers and microparticles including inhalable nanocomposites and nanoaggregates and on the optimization of such formulations using the proper techniques and carriers. Finally, the toxicological behavior and market potential of the inhalable anti-cancer drug delivery systems are discussed.

Author Keywords:Pulmonary drug delivery; Lung cancer; Nanocarriers; Microparticles; Nanocomposites; Nanoaggregates; Nanotoxicology

KeyWords Plus:NANOSTRUCTURED LIPID CARRIERS; LIPOSOME AEROSOL TREATMENT; COLONY-STIMULATING FACTOR; DRY POWDER INHALATION; LIQUID-CRYSTALLINE NANOPARTICLES; SUSTAINED-RELEASE MICROCARRIER; POLYMER HYBRID NANOPARTICLES; TARGETED PULMONARY DELIVERY; LINKED CASEIN NANOPARTICLES; IN-VIVO PHARMACOKINETICS

Reprint Address: Elzoghby, AO (reprint author)

Alexandria Univ, Dept Ind Pharmacyx, Fac Pharm, Alexandria 21521, Egypt.

Chang Gung Mem Hosp, Dept Anesthesiol, Taoyuan 333, Taiwan.

Addresses:

	[ 1 ] Alexandria Univ, CNRL, Fac Pharm, Alexandria 21521, Egypt
	[ 2 ] Alexandria Univ, Dept Ind Pharmacyx, Fac Pharm, Alexandria 21521, Egypt
	[ 3 ] PUA, Dept Pharmaceut, Fac Pharm, Alexandria, Egypt
	[ 4 ] Alexandria Univ, Dept Pharmaceut, Fac Pharm, Alexandria 21521, Egypt
	[ 5 ] Chang Gung Univ, Grad Inst Nat Prod, Pharmaceut Lab, Taoyuan 333, Taiwan
	[ 6 ] Chang Gung Univ Sci & Technol, Res Ctr Ind Human Ecol, Taoyuan 333, Taiwan
	[ 7 ] Chang Gung Univ Sci & Technol, Res Ctr Chinese Herbal Med, Taoyuan 333, Taiwan
	[ 8 ] Chang Gung Mem Hosp, Dept Anesthesiol, Taoyuan 333, Taiwan

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Research Areas:Chemistry; Pharmacology & Pharmacy

Web of Science Categories:Chemistry, Multidisciplinary; Pharmacology & Pharmacy